TLE4

Across TCGA patient cohorts, TLE4 mutation is significantly associated with the RNA expression of many other genes, with 4,869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE4-associated genes across cancer lineages are CLSPN, PSMB2, and SNRPA1. Each is linked with TLE4 in more than 4 cancer types. Because this analysis shows association rather than direction, both TLE4-to-partner and partner-to-TLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLSPN grouped by TLE4-low versus TLE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE4→partner) and Y-score (partner→TLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLSPN →	+0.680	+2.616	<.001	<.001	3	5
COAD	PSMB2 →	+0.394	+3.527	<.001	.002	3	4
UCEC	SNRPA1 →	+0.379	+1.984	<.001	<.001	3	4
UCEC	COQ3 →	+0.321	+1.332	.003	.001	3	4
COAD	MIS18A →	+0.451	+3.519	.001	.002	3	4
UCEC	ZNF367 →	+0.639	+1.788	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,869 associations by consensus.

CLSPN by TLE4 expression — UCEC

Explore this box plot interactively →