TLE4

Across TCGA cell cohorts, TLE4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,456 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TLE4-associated GO terms across cancer lineages are Regulation of chromosome separation, Golgi vesicle transport, and Negative regulation of endodermal cell differentiation. Each is linked with TLE4 in more than 8 cancer types. Because this analysis shows association rather than direction, both TLE4-to-partner and partner-to-TLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome separation grouped by TLE4-low versus TLE4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE4→partner) and Y-score (partner→TLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of chromosome separation →	+0.135	+2.084	<.001	<.001	3	9
SOFT_TISSUE	Golgi vesicle transport →	+0.052	+2.809	<.001	<.001	3	9
SKIN	Negative regulation of endodermal cell differentiation →	+1.013	+1.997	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Ventricular trabecula myocardium morphogenesis →	+0.160	+2.728	.001	<.001	3	9
SKIN	Microtubule cytoskeleton organization involved in mitosis →	+0.070	+1.880	.007	<.001	3	9
BONE	Regulation of plasma membrane repair →	+0.352	+2.731	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,456 associations by consensus.

Regulation of chromosome separation by TLE4 expression — OVARY

Explore this box plot interactively →