TLE4

Across TCGA cell cohorts, TLE4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLE4-associated genes across cancer lineages are ZIM2, AQP12B, and PRRG3. Each is linked with TLE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE4-to-partner and partner-to-TLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIM2 grouped by TLE4-low versus TLE4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE4→partner) and Y-score (partner→TLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZIM2 →	+0.027	+5.000	.006	.006	3	1
LUNG_NSCLC_LUAD	AQP12B →	+0.019	+4.417	.001	.004	3	1
BLOOD_Lymphoma	PRRG3 →	+0.300	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	CALHM4 →	+0.254	+3.765	<.001	.001	3	1
BLOOD_Lymphoma	OR51I1 →	+0.255	+3.192	<.001	.008	3	1
BLOOD_Lymphoma	OR56A4 →	+0.048	+3.342	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ZIM2 by TLE4 expression — PANCREAS

Explore this box plot interactively →