TLE2

Across TCGA patient cohorts, TLE2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,109 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TLE2-associated genes across cancer lineages are IRF5, TRAF7, and NMT1. Each is linked with TLE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE2-to-partner and partner-to-TLE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLE2 versus IRF5 in CCRCC, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE2→partner) and Y-score (partner→TLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRF5 →	-0.717	-0.694	.002	<.001	3	3
UCEC	TRAF7 →	-0.647	-0.267	.003	.008	3	2
UCEC	NMT1 →	-0.496	-0.273	.002	.007	3	2
CCRCC	IGSF11 →	-0.819	-0.809	<.001	<.001	3	2
CCRCC	RGS14 →	-0.732	-0.773	<.001	<.001	3	2
CCRCC	RPL15 →	+0.460	+0.491	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

TLE2 vs IRF5 — CCRCC

Explore this scatter interactively →