TLE2

Across TCGA patient cohorts, TLE2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE2-associated genes across cancer lineages are eIF4E, PRDX1, and ATM. Each is linked with TLE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE2-to-partner and partner-to-TLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TLE2-low versus TLE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE2→partner) and Y-score (partner→TLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.230	+3.906	.001	<.001	3	2
UCEC	PRDX1 →	+0.214	+1.700	.003	.040	3	2
UCEC	ATM →	-0.460	-2.000	.004	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.901	+2.926	<.001	<.001	3	2
SKCM	PAI-1 →	-0.649	-2.098	.024	.018	3	1
SKCM	Syk →	-0.510	-3.169	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by TLE2 expression — UCEC

Explore this box plot interactively →