TLE1P1

Across TCGA pan-cancer cohorts, TLE1P1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TLE1P1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TLE1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types TLE1P1 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

THCA, HNSC, and KIRP are the cancer types where TLE1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLE1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.120	<.001	11	view →
HNSC	Male	III,IV	+0.808	<.001	11	view →
KIRP	Female	All	+0.980	.010	8	view →
READ	All	II,III,IV	−1.255	.002	6	view →
BRCA	All	II,III,IV	−0.592	<.001	6	view →
LIHC	Male	All	+0.655	<.001	5	view →
LUSC	All	All	+0.382	.002	4	view →
LUAD	All	All	+0.349	<.001	3	view →
PAAD	Female	All	−0.859	.010	2	view →
CHOL	Female	All	+0.813	.038	1	view →
STAD	Male	II,III,IV	+0.465	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TLE1P1–THCA

Open the THCA breakdown →