Across TCGA patient cohorts, TLE1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,396 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TLE1-associated genes across cancer lineages are TLE1P1, SMC5, and TLE4. Each is linked with TLE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TLE1-to-partner and partner-to-TLE1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE1→partner) and Y-score (partner→TLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLE1P1 →	+1.180	+0.370	<.001	<.001	3	5
HNSC	SMC5 →	+0.744	+0.278	<.001	.002	3	4
BRCA	TLE4 →	+0.481	+0.485	<.001	<.001	3	3
GBM	ADGRL2 →	+0.616	+0.266	.003	<.001	3	3
CCRCC	RHOJ →	+0.770	+0.320	<.001	<.001	3	3
LUAD	ITPRID2 →	+0.349	+0.181	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,396 associations by consensus.

Exploration

TLE1 survival (RNA) · tumor vs normal (RNA) · all TLE1 data types