Across TCGA patient cohorts, TLE1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE1-associated genes across cancer lineages are JNK2, NF2, and p27_pT198. Each is linked with TLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE1-to-partner and partner-to-TLE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE1→partner) and Y-score (partner→TLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.213	+1.512	<.001	.017	3	2
UCEC	NF2 →	+0.179	+1.874	.009	.049	3	2
UCEC	p27_pT198 →	+0.097	+2.700	.004	.005	3	2
UCEC	p62 Lck ligand →	+0.326	+2.058	.001	<.001	3	2
UCEC	Rab25 →	-0.225	-2.459	.034	.018	3	2
UCEC	4E-BP1 →	+0.275	+2.029	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

TLE1 survival (RNA) · tumor vs normal (RNA) · all TLE1 data types