Across TCGA cell cohorts, TLE1 mutation is significantly associated with the RNA expression of many other genes, with 496 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLE1-associated genes across cancer lineages are OR13D1, OR13C3, and ZNF705D. Each is linked with TLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE1-to-partner and partner-to-TLE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE1→partner) and Y-score (partner→TLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR13D1 →	+0.032	+4.217	<.001	.005	3	1
CNS	OR13C3 →	+0.049	+5.321	<.001	.005	3	1
BLOOD_Lymphoma	ZNF705D →	+0.008	+3.927	.001	.004	3	1
BLOOD_Lymphoma	LY6G6D →	+0.113	+4.070	<.001	.004	3	1
BLOOD_Lymphoma	OR52B2 →	+0.020	+3.714	.003	.006	3	1
LUNG_SCLC	SIGLEC5 →	+0.076	+4.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 496 associations by consensus.

Exploration

TLE1 survival (RNA) · tumor vs normal (RNA) · all TLE1 data types