TLDC2

Across TCGA patient cohorts, TLDC2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TLDC2-associated genes across cancer lineages are Osteoblast, Melanocytes, and Basophils. Each is linked with TLDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLDC2-to-partner and partner-to-TLDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Osteoblast grouped by TLDC2-low versus TLDC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLDC2→partner) and Y-score (partner→TLDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Osteoblast →	+0.039	+3.494	.005	.030	3	1
SKCM	Melanocytes →	+0.073	+3.188	.020	.010	3	1
SKCM	Basophils →	+0.192	+2.189	.015	.035	3	1
SKCM	Endothelial cells →	-0.046	-3.315	.022	.010	1	1
SKCM	mv Endothelial cells →	-0.028	-3.315	.042	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Osteoblast by TLDC2 expression — LUAD

Explore this box plot interactively →