TLDC2

Across TCGA cell cohorts, TLDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,496 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TLDC2-associated GO terms across cancer lineages are Promoter clearance during DNA-templated transcription, RNA polymerase II promoter clearance, and Negative regulation of type I interferon-mediated signaling pathway. Each is linked with TLDC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TLDC2-to-partner and partner-to-TLDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Promoter clearance during DNA-templated transcription grouped by TLDC2-low versus TLDC2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLDC2→partner) and Y-score (partner→TLDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Promoter clearance during DNA-templated transcription →	+0.111	+0.482	<.001	<.001	3	9
URINARY_TRACT	RNA polymerase II promoter clearance →	+0.111	+0.482	<.001	<.001	3	9
CNS	Negative regulation of type I interferon-mediated signaling pathway →	+0.139	+0.486	<.001	.002	3	9
BREAST	Negative regulation of myoblast fusion →	+0.131	+0.567	<.001	<.001	3	9
OVARY	Regulation of type I interferon-mediated signaling pathway →	+0.100	+0.761	.001	.005	3	8
BLOOD_Lymphoma	Formation of cytoplasmic translation initiation complex →	+0.101	+0.454	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,496 associations by consensus.

Promoter clearance during DNA-templated transcription by TLDC2 expression — URINARY_TRACT

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