TLDC2

Across TCGA cell cohorts, TLDC2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLDC2-associated genes across cancer lineages are VCX2, GPHB5, and HIGD1C. Each is linked with TLDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLDC2-to-partner and partner-to-TLDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCX2 grouped by TLDC2-low versus TLDC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLDC2→partner) and Y-score (partner→TLDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VCX2 →	+1.507	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPHB5 →	+0.032	+5.022	<.001	.002	3	1
LARGE_INTESTINE	HIGD1C →	+0.065	+4.415	<.001	.007	3	1
LARGE_INTESTINE	NME8 →	+0.440	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VCX2 by TLDC2 expression — LARGE_INTESTINE

Explore this box plot interactively →