TLCD4

Across TCGA patient cohorts, TLCD4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLCD4-associated genes across cancer lineages are C-Raf, FASN, and Caveolin-1. Each is linked with TLCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD4-to-partner and partner-to-TLCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TLCD4-low versus TLCD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD4→partner) and Y-score (partner→TLCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.212	+3.000	.010	.037	3	1
UCEC	FASN →	+0.464	+3.000	.042	.037	2	1
UCEC	Caveolin-1 →	-1.023	-3.000	.014	.036	2	1
UCEC	MEK1 →	+0.685	+3.000	.001	.037	1	1
UCEC	TFRC →	+0.655	+3.000	.032	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C-Raf by TLCD4 expression — UCEC

Explore this box plot interactively →