Across TCGA cell cohorts, TLCD2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TLCD2-associated genes across cancer lineages are TOPAZ1, CETN1, and OR56A1. Each is linked with TLCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD2-to-partner and partner-to-TLCD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD2→partner) and Y-score (partner→TLCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TOPAZ1 →	+0.013	+6.022	<.001	.001	3	1
SKIN	CETN1 →	+0.013	+6.022	<.001	.001	3	1
SKIN	OR56A1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	CCDC172 →	+0.006	+5.415	<.001	.004	3	1
SKIN	CYLC1 →	+0.013	+5.415	<.001	.004	3	1
SKIN	IL31 →	+0.025	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TLCD2 survival (RNA) · tumor vs normal (RNA) · all TLCD2 data types