TLCD1

Across TCGA patient cohorts, TLCD1 mutation is significantly associated with the RNA expression of many other genes, with 282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLCD1-associated genes across cancer lineages are LINC01730, PRORP, and ATG4A. Each is linked with TLCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD1-to-partner and partner-to-TLCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01730 grouped by TLCD1-low versus TLCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD1→partner) and Y-score (partner→TLCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01730 →	+0.603	+3.459	<.001	.005	3	1
UCEC	PRORP →	+0.368	+3.470	.008	.003	3	1
UCEC	ATG4A →	+0.578	+3.370	.002	.004	3	1
UCEC	MON1B →	+0.500	+3.513	.005	.002	3	1
UCEC	OAZ1 →	+0.527	+3.338	<.001	.005	3	1
UCEC	SGTA →	+0.587	+3.480	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 282 associations by consensus.

LINC01730 by TLCD1 expression — UCEC

Explore this box plot interactively →