TLCD1

Across TCGA patient cohorts, TLCD1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLCD1-associated genes across cancer lineages are MSH2, Shc_pY317, and EGFR_pY1068. Each is linked with TLCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLCD1-to-partner and partner-to-TLCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by TLCD1-low versus TLCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLCD1→partner) and Y-score (partner→TLCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.387	-2.973	.001	.035	3	1
UCEC	Shc_pY317 →	-0.219	-3.169	.005	.019	3	1
UCEC	EGFR_pY1068 →	-0.291	-3.321	.026	.010	1	1
UCEC	ERK2 →	+0.317	+3.321	.001	.010	1	1
UCEC	4E-BP1 →	+0.519	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MSH2 by TLCD1 expression — UCEC

Explore this box plot interactively →