TKTL2

Across TCGA patient cohorts, TKTL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,832 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TKTL2-associated GO terms across cancer lineages are Regulation of chromosome organization, Positive regulation of double-strand break repair via homologous recombination, and Protein polyubiquitination. Each is linked with TKTL2 in more than 21 cancer types. Because this analysis shows association rather than direction, both TKTL2-to-partner and partner-to-TKTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome organization grouped by TKTL2-low versus TKTL2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL2→partner) and Y-score (partner→TKTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of chromosome organization →	+0.062	+0.081	<.001	<.001	3	22
STAD	Positive regulation of double-strand break repair via homologous recombination →	+0.076	+0.140	<.001	<.001	3	21
STAD	Protein polyubiquitination →	+0.067	+0.103	<.001	<.001	3	21
STAD	TOR signaling →	+0.056	+0.102	<.001	<.001	3	21
STAD	Regulation of protein ubiquitination →	+0.050	+0.077	<.001	<.001	3	21
STAD	Positive regulation of peptidase activity →	+0.058	+0.108	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,832 associations by consensus.

Regulation of chromosome organization by TKTL2 expression — STAD

Explore this box plot interactively →