TKTL2

Across TCGA patient cohorts, TKTL2 mutation is significantly associated with the RNA expression of many other genes, with 5,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKTL2-associated genes across cancer lineages are DYNC2I2, MRPS2, and CKS2. Each is linked with TKTL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TKTL2-to-partner and partner-to-TKTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNC2I2 grouped by TKTL2-low versus TKTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL2→partner) and Y-score (partner→TKTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DYNC2I2 →	+0.412	+3.828	.003	<.001	3	4
UCEC	MRPS2 →	+0.433	+4.010	<.001	<.001	3	4
UCEC	CKS2 →	+0.644	+1.857	<.001	<.001	3	4
LUAD	KPNA2 →	+0.669	+2.816	.002	.001	3	4
UCEC	C16orf95 →	+0.254	+1.857	<.001	<.001	3	4
LUAD	MAD2L1 →	+0.820	+2.217	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,271 associations by consensus.

DYNC2I2 by TKTL2 expression — UCEC

Explore this box plot interactively →