TKTL2

Across TCGA patient cohorts, TKTL2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKTL2-associated genes across cancer lineages are ATM, MIG-6, and Cyclin-B1. Each is linked with TKTL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TKTL2-to-partner and partner-to-TKTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TKTL2-low versus TKTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL2→partner) and Y-score (partner→TKTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.444	-1.700	.001	.001	3	5
LUAD	MIG-6 →	+0.267	+3.186	.001	.009	3	3
UCEC	Cyclin-B1 →	+0.653	+2.906	<.001	.001	3	3
UCEC	eIF4E →	+0.166	+2.713	.009	.003	3	3
UCEC	STAT3_pY705 →	-0.295	-1.263	<.001	.019	3	3
UCEC	4E-BP1 →	+0.251	+3.700	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by TKTL2 expression — UCEC

Explore this box plot interactively →