TKTL2

Across TCGA cell cohorts, TKTL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 868 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TKTL2-associated GO terms across cancer lineages are Regulation of protein modification by small protein conjugation or removal, Protein modification by small protein removal, and Adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Each is linked with TKTL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TKTL2-to-partner and partner-to-TKTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein modification by small protein conjugation or removal grouped by TKTL2-low versus TKTL2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL2→partner) and Y-score (partner→TKTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of protein modification by small protein conjugation or removal →	+0.032	+0.008	.002	.007	3	5
URINARY_TRACT	Protein modification by small protein removal →	+0.049	+0.021	<.001	.006	2	6
PANCREAS	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.041	-0.013	.006	.006	3	5
SOFT_TISSUE	Regulation of defense response to virus by host →	+0.075	+0.013	<.001	.006	3	5
KIDNEY	Negative regulation of alpha-beta T cell differentiation →	+0.064	+0.047	<.001	.004	3	4
SOFT_TISSUE	Positive regulation of viral life cycle →	+0.091	+0.017	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 868 associations by consensus.

Regulation of protein modification by small protein conjugation or removal by TKTL2 expression — SKIN

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