TKTL2

Across TCGA cell cohorts, TKTL2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TKTL2-associated genes across cancer lineages are OR8B8, SIM1, and SLC5A7. Each is linked with TKTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TKTL2-to-partner and partner-to-TKTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B8 grouped by TKTL2-low versus TKTL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL2→partner) and Y-score (partner→TKTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B8 →	+0.013	+2.827	.005	.004	3	2
LUNG_NSCLC_LUAD	SIM1 →	+0.414	+3.040	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLC5A7 →	+0.051	+2.977	.002	.001	3	1
LUNG_NSCLC_LUAD	GH2 →	+0.035	+2.637	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR1J1 →	+0.177	+3.763	.002	.002	3	1
LUNG_NSCLC_LUAD	UNC13C →	+0.065	+3.940	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR8B8 by TKTL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →