TKTL1

Across TCGA pan-cancer cohorts, TKTL1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TKTL1 data layer compared with 18 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TKTL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TKTL1 expression acts as an unfavorable survival marker.

LUAD and GBM are the cancer types where TKTL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.231	0.831	.016	14	view →
GBM	DFS	Quartile	All	0.306	0.834	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TKTL1–LUAD (OS)

Open the LUAD breakdown →