TKTL1

Across TCGA patient cohorts, TKTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,075 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible TKTL1-associated GO terms across cancer lineages are Regulation of calcium ion export across plasma membrane, Nucleobase-containing compound transport, and Regulation of protein ubiquitination. Each is linked with TKTL1 in more than 17 cancer types. Because this analysis shows association rather than direction, both TKTL1-to-partner and partner-to-TKTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of calcium ion export across plasma membrane grouped by TKTL1-low versus TKTL1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL1→partner) and Y-score (partner→TKTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of calcium ion export across plasma membrane →	+0.059	+0.819	<.001	<.001	2	18
STAD	Nucleobase-containing compound transport →	+0.075	+0.808	<.001	<.001	3	17
STAD	Regulation of protein ubiquitination →	+0.053	+0.560	<.001	<.001	3	17
STAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.078	+0.781	<.001	<.001	3	17
STAD	Sex-chromosome dosage compensation →	+0.063	+0.486	<.001	.002	3	17
STAD	RNA localization →	+0.083	+0.842	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,075 associations by consensus.

Regulation of calcium ion export across plasma membrane by TKTL1 expression — STAD

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