TKTL1

Across TCGA patient cohorts, TKTL1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKTL1-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with TKTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TKTL1-to-partner and partner-to-TKTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by TKTL1-low versus TKTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL1→partner) and Y-score (partner→TKTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.134	+2.026	.012	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.704	+2.827	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.213	-2.000	.016	.003	3	1
UCEC	GATA6 →	-0.118	-1.700	.034	.042	3	1
UCEC	MEK1 →	+0.488	+3.700	<.001	.001	3	1
UCEC	Notch1 →	+0.148	+1.817	.002	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TIGAR by TKTL1 expression — UCEC

Explore this box plot interactively →