TKTL1

Across TCGA cell cohorts, TKTL1 mutation is significantly associated with the mutation status of many other genes, with 3,017 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TKTL1-associated genes across cancer lineages are SEL1L2, STIL, and PLEKHA7. Each is linked with TKTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TKTL1-to-partner and partner-to-TKTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by TKTL1-low versus TKTL1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKTL1→partner) and Y-score (partner→TKTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEL1L2 →	+4.297	+4.857	.009	.009	1	3
LUNG_NSCLC_LUAD	STIL →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	PLEKHA7 →	+4.187	+5.000	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	ATP1A4 →	+4.954	+4.392	.008	.008	1	3
LARGE_INTESTINE	DIP2A →	+3.321	+3.544	<.001	<.001	1	3
LARGE_INTESTINE	SLC45A1 →	+3.263	+4.056	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,017 associations by consensus.

SEL1L2 by TKTL1 expression — BREAST

Explore this box plot interactively →