TKT

Across TCGA patient cohorts, TKT mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKT-associated genes across cancer lineages are eIF4E, C-Raf, and 14-3-3_beta. Each is linked with TKT in more than 1 cancer types. Because this analysis shows association rather than direction, both TKT-to-partner and partner-to-TKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TKT-low versus TKT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKT→partner) and Y-score (partner→TKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.195	+2.598	.016	.005	3	2
UCEC	C-Raf →	+0.198	+2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.133	-3.558	<.001	.002	3	1
UCEC	ERK2 →	+0.162	+3.169	.028	.018	3	1
UCEC	FoxM1 →	+0.325	+2.232	.001	.005	3	1
UCEC	Heregulin →	-0.133	-1.678	.004	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by TKT expression — UCEC

Explore this box plot interactively →