TKT

Across TCGA cell cohorts, TKT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,605 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TKT-associated GO terms across cancer lineages are Response to L-phenylalanine derivative, Response to thyroxine, and Response to hepatocyte growth factor. Each is linked with TKT in more than 10 cancer types. Because this analysis shows association rather than direction, both TKT-to-partner and partner-to-TKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to L-phenylalanine derivative grouped by TKT-low versus TKT-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TKT→partner) and Y-score (partner→TKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to L-phenylalanine derivative →	+0.211	+1.042	<.001	<.001	3	11
LIVER	Response to thyroxine →	+0.153	+0.897	<.001	.005	3	10
URINARY_TRACT	Response to hepatocyte growth factor →	+0.113	+1.063	.002	<.001	2	10
OVARY	Cellular response to hepatocyte growth factor stimulus →	+0.117	+0.834	<.001	.006	3	9
LUNG_NSCLC_LUSC	Glyceraldehyde-3-phosphate biosynthetic process →	+0.168	+1.121	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Pyrimidine deoxyribonucleotide biosynthetic process →	+0.170	+1.100	.003	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

Response to L-phenylalanine derivative by TKT expression — LUNG_SCLC

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