TKT

Across TCGA cell cohorts, TKT mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TKT-associated genes across cancer lineages are TSPAN16, OR52A1, and BPY2. Each is linked with TKT in more than 1 cancer types. Because this analysis shows association rather than direction, both TKT-to-partner and partner-to-TKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by TKT-low versus TKT-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKT→partner) and Y-score (partner→TKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TSPAN16 →	+0.035	+3.977	<.001	.006	3	1
LIVER	OR52A1 →	+0.027	+3.977	<.001	.006	3	1
LARGE_INTESTINE	BPY2 →	+0.018	+4.437	<.001	.004	3	1
LARGE_INTESTINE	BPY2B →	+0.018	+4.437	<.001	.004	3	1
LARGE_INTESTINE	BPY2C →	+0.018	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TSPAN16 by TKT expression — LIVER

Explore this box plot interactively →