TK1

Across TCGA cell cohorts, TK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,992 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible TK1-associated GO terms across cancer lineages are Mitotic DNA replication, DNA replication checkpoint signaling, and Pyrimidine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with TK1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TK1-to-partner and partner-to-TK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by TK1-low versus TK1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TK1→partner) and Y-score (partner→TK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Mitotic DNA replication →	+0.202	+1.429	<.001	.001	3	17
OESOPHAGUS	DNA replication checkpoint signaling →	+0.206	+1.594	.001	.002	3	17
BREAST	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.200	+1.464	<.001	<.001	3	17
BONE	Nuclear chromosome segregation →	+0.134	+1.653	.007	<.001	3	17
BONE	Thymidine biosynthetic process →	+0.215	+1.900	<.001	<.001	3	17
BONE	2'-deoxyribonucleoside biosynthetic process →	+0.215	+1.900	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,992 associations by consensus.

Mitotic DNA replication by TK1 expression — OESOPHAGUS

Explore this box plot interactively →