TJP3

Across TCGA patient cohorts, TJP3 mutation is significantly associated with the RNA expression of many other genes, with 3,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TJP3-associated genes across cancer lineages are TPT1P11, HIRA, and WNT5B. Each is linked with TJP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TJP3-to-partner and partner-to-TJP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPT1P11 grouped by TJP3-low versus TJP3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP3→partner) and Y-score (partner→TJP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TPT1P11 →	+0.147	+5.418	<.001	.005	3	3
UCEC	HIRA →	+0.376	+2.120	<.001	<.001	3	3
SKCM	WNT5B →	-0.478	-2.513	.003	<.001	3	3
UCEC	DDAH1 →	+0.597	+2.523	<.001	<.001	3	3
UCEC	OXA1L →	+0.245	+2.042	.002	.001	3	3
UCEC	SUPV3L1 →	+0.313	+2.364	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,032 associations by consensus.

TPT1P11 by TJP3 expression — CESC

Explore this box plot interactively →