TJP3

Across TCGA patient cohorts, TJP3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TJP3-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and ATM. Each is linked with TJP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TJP3-to-partner and partner-to-TJP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TJP3-low versus TJP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP3→partner) and Y-score (partner→TJP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.729	+1.522	<.001	.017	3	4
COAD	Caveolin-1 →	-0.882	-3.161	.011	.019	3	4
UCEC	ATM →	-0.413	-1.716	.004	.003	3	3
UCEC	eIF4E →	+0.189	+3.713	.005	<.001	3	2
UCEC	NF2 →	+0.170	+2.222	.015	.010	3	2
UCEC	Rad50 →	-0.167	-1.222	.034	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by TJP3 expression — UCEC

Explore this box plot interactively →