TJP3

Across TCGA cell cohorts, TJP3 mutation is significantly associated with the mutation status of many other genes, with 1,679 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TJP3-associated genes across cancer lineages are DLEC1, SEZ6L, and UGGT2. Each is linked with TJP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TJP3-to-partner and partner-to-TJP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLEC1 grouped by TJP3-low versus TJP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP3→partner) and Y-score (partner→TJP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DLEC1 →	+2.493	+2.758	.007	.007	1	4
SOFT_TISSUE	SEZ6L →	+5.066	+4.502	.007	.007	1	4
LUNG_NSCLC_LUAD	UGGT2 →	+5.772	+5.772	.002	.002	1	4
CNS	HK3 →	+4.277	+4.584	.001	.001	1	4
SKIN	XKR7 →	+4.247	+2.807	.007	.007	1	4
BLOOD_Leukemia	CDC42BPB →	+2.177	+2.774	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,679 associations by consensus.

DLEC1 by TJP3 expression — BLOOD_Leukemia

Explore this box plot interactively →