TJP2

Across TCGA patient cohorts, TJP2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TJP2-associated genes across cancer lineages are eIF4E, PREX1, and PCNA. Each is linked with TJP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TJP2-to-partner and partner-to-TJP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TJP2-low versus TJP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP2→partner) and Y-score (partner→TJP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.199	+2.610	.007	.005	3	3
COAD	PREX1 →	+0.313	+1.900	<.001	.030	3	3
COAD	PCNA →	+0.263	+1.882	.011	.031	3	2
COAD	PTEN →	+0.142	+1.882	.015	.031	3	2
COAD	ASNS →	+0.485	+3.708	.003	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.996	+3.708	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eIF4E by TJP2 expression — COAD

Explore this box plot interactively →