TJP2

Across TCGA cell cohorts, TJP2 mutation is significantly associated with the RNA expression of many other genes, with 747 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TJP2-associated genes across cancer lineages are FAM160A1, HTN1, and NOX3. Each is linked with TJP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TJP2-to-partner and partner-to-TJP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by TJP2-low versus TJP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP2→partner) and Y-score (partner→TJP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM160A1 →	+0.617	+2.584	.006	.002	3	2
URINARY_TRACT	HTN1 →	+0.157	+4.044	.003	.001	3	1
URINARY_TRACT	NOX3 →	+0.278	+3.807	.005	.005	3	1
CNS	CLPS →	+0.070	+4.169	<.001	.008	3	1
CNS	TBATA →	+0.014	+4.772	<.001	.002	3	1
CNS	APOB →	+0.027	+3.978	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 747 associations by consensus.

FAM160A1 by TJP2 expression — LARGE_INTESTINE

Explore this box plot interactively →