TJP1

Across TCGA patient cohorts, TJP1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,232 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TJP1-associated genes across cancer lineages are DENND2A, HOPX, and PTPN21. Each is linked with TJP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TJP1-to-partner and partner-to-TJP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TJP1 versus DENND2A in GBM, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP1→partner) and Y-score (partner→TJP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DENND2A →	+0.871	+0.259	.001	.001	3	7
HNSC	HOPX →	+1.235	+0.245	<.001	<.001	3	7
CCRCC	PTPN21 →	+0.658	+0.327	<.001	<.001	3	7
UCEC	PGM5 →	+1.278	+0.341	<.001	<.001	3	6
CCRCC	CSDC2 →	+1.054	+0.224	<.001	<.001	3	6
CCRCC	ABCG2 →	+1.110	+0.262	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,232 associations by consensus.

TJP1 vs DENND2A — GBM

Explore this scatter interactively →