TJP1

Across TCGA patient cohorts, TJP1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TJP1-associated genes across cancer lineages are 4E-BP1, Cyclin-E2, and ASNS. Each is linked with TJP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TJP1-to-partner and partner-to-TJP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TJP1-low versus TJP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP1→partner) and Y-score (partner→TJP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.258	+2.584	.039	.010	3	5
BRCA	Cyclin-E2 →	+0.322	+2.814	.006	.037	3	4
COAD	ASNS →	+0.668	+3.321	<.001	.009	3	4
STAD	Cyclin-B1 →	+0.454	+2.584	.019	.010	3	3
COAD	PAI-1 →	+0.791	+2.824	.001	.034	3	3
UCEC	JNK2 →	+0.212	+1.784	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

4E-BP1 by TJP1 expression — STAD

Explore this box plot interactively →