TJP1

Across TCGA cell cohorts, TJP1 mutation is significantly associated with the RNA expression of many other genes, with 1,054 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TJP1-associated genes across cancer lineages are RCN2, OR3A2, and C20orf173. Each is linked with TJP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TJP1-to-partner and partner-to-TJP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCN2 grouped by TJP1-low versus TJP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TJP1→partner) and Y-score (partner→TJP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RCN2 →	+0.524	+3.321	<.001	.003	3	3
LUNG_NSCLC_LUSC	OR3A2 →	+0.404	+4.108	.006	.005	3	2
OVARY	C20orf173 →	+0.023	+4.029	.001	.009	3	2
OVARY	USP17L3 →	+0.006	+4.228	<.001	.006	3	2
LARGE_INTESTINE	GCAT →	+1.225	+3.321	<.001	.002	3	2
LARGE_INTESTINE	ST13 →	+0.508	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,054 associations by consensus.

RCN2 by TJP1 expression — LARGE_INTESTINE

Explore this box plot interactively →