TIRAP

Across TCGA patient cohorts, TIRAP mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIRAP-associated genes across cancer lineages are PCNA, Rad50, and ATM. Each is linked with TIRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both TIRAP-to-partner and partner-to-TIRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TIRAP-low versus TIRAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIRAP→partner) and Y-score (partner→TIRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.233	+2.459	.025	.020	3	2
UCEC	Rad50 →	-0.304	-2.459	.009	.020	3	2
UCEC	ATM →	-0.584	-2.459	.007	.020	3	2
UCEC	ER-alpha_pS118 →	-0.392	-2.459	.023	.020	3	1
UCEC	ERK2 →	+0.263	+3.584	.004	.002	3	1
UCEC	Annexin-1 →	+0.748	+3.019	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by TIRAP expression — UCEC

Explore this box plot interactively →