TIRAP

Across TCGA cell cohorts, TIRAP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,267 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TIRAP-associated GO terms across cancer lineages are Regulation of chemokine (C-X-C motif) ligand 1 production, Positive regulation of chemokine (C-X-C motif) ligand 1 production, and Toll-like receptor TLR1:TLR2 signaling pathway. Each is linked with TIRAP in more than 16 cancer types. Because this analysis shows association rather than direction, both TIRAP-to-partner and partner-to-TIRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chemokine (C-X-C motif) ligand 1 production grouped by TIRAP-low versus TIRAP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIRAP→partner) and Y-score (partner→TIRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of chemokine (C-X-C motif) ligand 1 production →	+1.311	+0.845	.001	.003	3	17
LUNG_NSCLC_LUSC	Positive regulation of chemokine (C-X-C motif) ligand 1 production →	+1.311	+0.845	.001	.003	3	17
BLOOD_Myeloma	Toll-like receptor TLR1:TLR2 signaling pathway →	+1.120	+0.936	<.001	<.001	3	14
OVARY	Positive regulation of TORC2 signaling →	+0.107	+0.966	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Copper ion export →	-0.163	-0.698	<.001	.002	3	12
OESOPHAGUS	Receptor recycling →	+0.080	+0.898	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,267 associations by consensus.

Regulation of chemokine (C-X-C motif) ligand 1 production by TIRAP expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →