TIPARP

Across TCGA pan-cancer cohorts, TIPARP Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TIPARP data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIPARP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TIPARP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, SARC, and BRCA are the cancer types where TIPARP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.139	0.685	.003	24	view →
SARC	OS	Median	All	0.108	0.839	<.001	12	view →
BRCA	OS	Median	All	0.107	0.578	.006	12	view →
BLCA	DFS	Median	III,IV	0.106	0.549	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
UCEC	DFS	Median	All	0.910	0.622	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TIPARP–HNSC (OS)

Open the HNSC breakdown →