TIPARP

Across TCGA patient cohorts, TIPARP mutation is significantly associated with the RNA expression of many other genes, with 3,558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIPARP-associated genes across cancer lineages are MIR4444-2, YTHDF3-AS1, and CRYBB2P1. Each is linked with TIPARP in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPARP-to-partner and partner-to-TIPARP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4444-2 grouped by TIPARP-low versus TIPARP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPARP→partner) and Y-score (partner→TIPARP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4444-2 →	+0.295	+2.148	<.001	.006	3	2
UCEC	YTHDF3-AS1 →	+0.515	+2.147	.001	.009	3	2
UCEC	CRYBB2P1 →	+0.549	+2.960	<.001	<.001	3	2
SKCM	NDUFC1 →	+0.449	+3.610	<.001	.001	3	2
SKCM	PSMD9 →	+0.437	+3.389	<.001	.004	3	2
SKCM	EIF2B1 →	+0.453	+2.826	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

MIR4444-2 by TIPARP expression — SKCM

Explore this box plot interactively →