TIPARP

Across TCGA patient cohorts, TIPARP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIPARP-associated genes across cancer lineages are ATM, Myosin-IIa_pS1943, and EGFR_pY1068. Each is linked with TIPARP in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPARP-to-partner and partner-to-TIPARP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TIPARP-low versus TIPARP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPARP→partner) and Y-score (partner→TIPARP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.565	-3.700	.001	.001	3	2
SKCM	Myosin-IIa_pS1943 →	+0.363	+3.339	.013	.005	3	1
UCEC	EGFR_pY1068 →	-0.316	-2.502	.001	.002	3	1
UCEC	ERK2 →	+0.218	+1.584	.003	.036	3	1
UCEC	GATA6 →	-0.167	-1.693	.011	.044	3	1
UCEC	ACC1 →	+0.324	+3.183	.023	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by TIPARP expression — UCEC

Explore this box plot interactively →