TIPARP

Across TCGA cell cohorts, TIPARP mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIPARP-associated genes across cancer lineages are REG1B, CCT8L2, and UTF1. Each is linked with TIPARP in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPARP-to-partner and partner-to-TIPARP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by TIPARP-low versus TIPARP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPARP→partner) and Y-score (partner→TIPARP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.981	+3.196	<.001	.007	3	2
BLOOD_Leukemia	CCT8L2 →	+0.013	+5.289	<.001	<.001	3	2
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.016	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR51D1 →	+0.011	+3.632	<.001	.003	3	1
BLOOD_Leukemia	SLC32A1 →	+0.499	+3.901	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

REG1B by TIPARP expression — LARGE_INTESTINE

Explore this box plot interactively →