TIMP4

Across TCGA patient cohorts, TIMP4 mutation is significantly associated with the RNA expression of many other genes, with 400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMP4-associated genes across cancer lineages are MIR3144, RNA5SP74, and RNU6-1155P. Each is linked with TIMP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIMP4-to-partner and partner-to-TIMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3144 grouped by TIMP4-low versus TIMP4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP4→partner) and Y-score (partner→TIMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR3144 →	+0.433	+7.954	<.001	.008	3	3
LUAD	RNA5SP74 →	+0.327	+5.712	.006	.003	3	2
UCEC	RNU6-1155P →	+0.158	+4.890	<.001	.002	3	2
SKCM	OR5M12P →	+0.035	+4.634	<.001	.003	3	2
HNSC	RNU6-243P →	+0.343	+7.954	<.001	.008	3	1
BLCA	RN7SL811P →	+0.213	+5.177	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 400 associations by consensus.

MIR3144 by TIMP4 expression — HNSC

Explore this box plot interactively →