TIMP4

Across TCGA patient cohorts, TIMP4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMP4-associated genes across cancer lineages are STAT3_pY705, ATM, and CD49b. Each is linked with TIMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP4-to-partner and partner-to-TIMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TIMP4-low versus TIMP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP4→partner) and Y-score (partner→TIMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.324	-3.000	.032	.037	3	1
UCEC	ATM →	-0.727	-3.000	.005	.037	3	1
UCEC	CD49b →	-0.449	-2.986	.006	.037	2	2
UCEC	ERK2 →	+0.241	+3.000	.030	.037	2	1
UCEC	PCNA →	+0.315	+3.000	.011	.036	2	1
UCEC	4E-BP1 →	+0.425	+2.837	.006	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

STAT3_pY705 by TIMP4 expression — UCEC

Explore this box plot interactively →