TIMP4

Across TCGA cell cohorts, TIMP4 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIMP4-associated genes across cancer lineages are SEL1L2, MMP27, and GUCA1C. Each is linked with TIMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP4-to-partner and partner-to-TIMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by TIMP4-low versus TIMP4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP4→partner) and Y-score (partner→TIMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CYP39A1 →	+0.114	+3.769	.009	.008	3	1
BLOOD_Leukemia	RGS7 →	+0.361	+3.769	<.001	.008	3	1
BLOOD_Leukemia	AQP12A →	+0.091	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SEL1L2 by TIMP4 expression — URINARY_TRACT

Explore this box plot interactively →