TIMP2

Across TCGA pan-cancer cohorts, TIMP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TIMP2 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TIMP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIMP2 expression acts as an unfavorable survival marker.

COAD, CCRCC, and LSCC are the cancer types where TIMP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	36	view →
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	25	view →
LSCC	DFS	Median	All	0.598	0.810	.005	18	view →
LUAD	OS	Median	III,IV	0.359	0.879	.003	14	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	10	view →
PDAC	OS	Quartile	All	0.290	0.557	.029	4	view →
GBM	DFS	Median	All	0.281	0.463	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TIMP2–COAD (DFS)

Open the COAD breakdown →