TIMP2

Across TCGA patient cohorts, TIMP2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMP2-associated genes across cancer lineages are ASNS, EGFR_pY1068, and EGFR. Each is linked with TIMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP2-to-partner and partner-to-TIMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TIMP2-low versus TIMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP2→partner) and Y-score (partner→TIMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.339	+2.222	.014	.010	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.087	.017	.005	3	1
UCEC	EGFR →	-0.186	-3.584	.002	.002	3	1
UCEC	eIF4E →	+0.206	+3.183	.011	.009	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.700	.003	.006	3	1
UCEC	FoxM1 →	+0.237	+2.087	.017	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by TIMP2 expression — UCEC

Explore this box plot interactively →