TIMP2

Across TCGA cell cohorts, TIMP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,606 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TIMP2-associated GO terms across cancer lineages are Negative regulation of metallopeptidase activity, Regulation of metallopeptidase activity, and Substrate adhesion-dependent cell spreading. Each is linked with TIMP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both TIMP2-to-partner and partner-to-TIMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metallopeptidase activity grouped by TIMP2-low versus TIMP2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP2→partner) and Y-score (partner→TIMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of metallopeptidase activity →	+0.572	+2.064	.007	.001	3	16
LUNG_NSCLC_LUSC	Regulation of metallopeptidase activity →	+0.276	+3.687	<.001	<.001	3	16
OESOPHAGUS	Substrate adhesion-dependent cell spreading →	+0.177	+3.887	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Response to hydrostatic pressure →	+0.222	+3.187	<.001	.004	3	14
STOMACH	Caveolin-mediated endocytosis →	+0.185	+3.269	.002	<.001	3	14
OESOPHAGUS	Regulation of proteolysis →	+0.105	+3.111	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,606 associations by consensus.

Negative regulation of metallopeptidase activity by TIMP2 expression — LUNG_SCLC

Explore this box plot interactively →