TIMP2

Across TCGA cell cohorts, TIMP2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIMP2-associated genes across cancer lineages are HOXB1, SPEM3, and HMX3. Each is linked with TIMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP2-to-partner and partner-to-TIMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXB1 grouped by TIMP2-low versus TIMP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP2→partner) and Y-score (partner→TIMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HOXB1 →	+0.023	+3.791	<.001	.007	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1
LARGE_INTESTINE	HMX3 →	+0.771	+3.531	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HOXB1 by TIMP2 expression — LARGE_INTESTINE

Explore this box plot interactively →